NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic
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NMR Analysis Demonstrates Immunoglobulin G N-glycans are Accessible and Dynamic
The N-glycan at Asn297 of the immunoglobulin G Fc fragment modulates cellular responses of the adaptive immune system. However, the underlying mechanism remains undefined, as existing structural data suggest the glycan does not directly engage cell surface receptors. Here we characterize the dynamics of the glycan termini using solution NMR spectroscopy. Contrary to previous conclusions based o...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2011
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.511